| Details: |
Product Name:2-Hydroxypropyl-β-cyclodextrin
CAS:128446-35-5
MF:C63H112O42
MW: 1541.54
Melting point 278 °C (dec.)
refractive index锛 125 ° (C=1, H2O)
solubility锛 H2O: 45 % (w/v)
color 锛歐hite to slightly yellow
optical activity锛 [α]26/D +139°, c = 1 in H2O
Water Solubility 锛 Soluble in water.
Chemical Properties 锛歐hite to slightly yellow powder
Uses锛 2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.enteric coating, sustained release formulations, buccal and transdermal drug delivery锛2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis锛孒ydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility. |
